The Landes Research Group at Rice University

The Landes Research Group develops new spectroscopic tools to image chemical dynamics at interfaces at the limit of a single event. Using this super-resolved chemical knowledge, we create new models to understand and predict macroscale processes like protein separation and photocatalysis.


Ensemble vs. Single Molecule

A wide range of biological and materials processes rely on nanoscale interfacial dynamics. Single molecule methods allow us to identify the chemical complexity of these interactions by revealing the underlying populations that form the ensemble measurement. In doing so, we can identify and tune the rare chemical populations that play a crucial role in reactivity.

Towards Predictive Separations

The cost of bringing a new protein based therapeutic to market averages ~$2.6 billion dollars, of which 50% can be dedicated to isolating and purifying the active compound. A primary contributor to the cost is the empirical optimization of chromatographic separation. Our lab seeks to understand separations from the scale of individual analytes, with a goal to create a new predictive model of chromatography to eliminate the need for costly empirical methods.


Breaking the Abbe-Diffraction Limit

The Abbe diffraction limit sets a lower bound of a few hundred nanometers for the size of objects we can observe with traditional optical microscopy. This limit is defined by light’s wavelength. Our lab develops new mathematical methods to break the Abbe diffraction limit and achieve spatial resolutions of just a few nanometers and time resolutions faster than traditional cameras frame times.

New Postdoctoral Scholar   08/22/2018

Miranda Gallagher

We are happy to welcome our new Postdoctoral Fellow, Miranda Gallagher, to our offices. Good luck in the years to come!

Departmental Achievement Awards   08/17/2018

Logan BishopNicholas Moringo

Congratulations to Logan Bishop and Nicholas Moringo for winning awards at this years departmental awards ceremony. Keep up the good work!

Lab Outing   07/05/2018

Landes group

The Super Group went to watch the Astros beat out the White Sox. 'GO STROS!

Quals Passed   04/26/2018

Charlotte Flatebo

Congratulations to Charlotte Flatebo for advancing to Ph.D. candidacy!

Predictive Separations

Predictive Separations



Protein Dynamics at Interfaces

Protein Dynamics at Interfaces

Imaging and Signal Processing

Imaging and Signal Processing

Single-Molecule Spectroscopy

Single-Molecule Spectroscopy

Hoener, B.S., Kirchner, S.R., Heiderscheit, T.S., Collins, S.S.E., Chang, W., Link, S., Landes, C.F., "Plasmonic Sensing and Control of Single-Nanoparticle Electrochemistry" Chem. 2018, 4:7, 1560-1585

Moringo, N.A., Shen, H., Bishop, L.D.C., Wang, W., Landes, C.F., "Enhancing Analytical Separations Using Super-Resolution Microscopy" Annu. Rev. Phys. Chem. 2018, 69:14, 1-14.23

Dolino, D.M., Chatterjee, S., MacLean, D.M., Flatebo, C., Bishop, L.D.C., Shaikh, S.A., Landes, C.F., Jayaraman, V., "The structure–energy landscape of NMDA receptor gating" Nat. Chem. Bio., 2017, 13, pp. 1232-1238

Kisley, L., Ujwal, P., Dhamane, S., Kourentzi, K., Tauzin, L.J., Wilson, R.C., Landes, C.F., "Competitive multicomponent anion exchange adsorption of proteins at the single molecule level" Analyst, 2017, 17(142), pp 3127-3131

Moringo, N.A., Shen, H., Tauzin, L.J., Wang, W., Bishop, L.D.C., Landes, C.F., "Variable Lysozyme Transport Dynamics on Oxidatively Functionalized Polystyrene Films" Langmuir, 2017, 33(41), pp 10818-10828

Rice University
Chemistry Department
Smalley-Curl Institute
ECE Department