Research Areas

Quantifying heterogeneous structure-function relationships one molecule at a time presents challenges for theory, experiment, and data analysis. We must develop new methods to collect, process, and understand super-resolved spectroscopic data to respond to the challenges of today's scientific problems. As such, our research focuses on three linked objectives:

  • Develop new spectroscopic data acquisition and analysis methods to image dynamics at nanoscale interfaces
  • Define testable hypotheses for protein separations by combining super-resolved protein adsorption and a stochastic theory of ion-exchange chromatography
  • Design methods to control photocatalysis at nanoparticle interfaces with the ultimate goal of controlling single electron transfer
Predictive Separations

Predictive Separations

Spectro-electrochemistry

Spectro-electrochemistry

Protein Dynamics at Interfaces

Protein Dynamics at Interfaces

Imaging and Signal Processing

Imaging and Signal Processing

Single-Molecule Spectroscopy

Single-Molecule Spectroscopy

Wallum,A.,Liu,Z.,Lee,J.,Chatterjee, S., Tauzin,L., Barr, C.D., Brown,A., Landes C. F., Nicely, A.L., Gruebele, M., "An Instrument Assembly and Data Science Lab for Early Undergraduate Education J. Chem. Educ. 2023 (2023)

Lee, S.A.,Kuhs, C.T., Searles,E.K.,Everitt, H.O., Link,S., Landes C. F., "d-Band Hole Dynamics in Gold Nanoparticles Measured with Time-Resolved Emission Upconversion Microscopy Nano Lett. 2023, 23, 8, 3501–3506 (2023)

Gross, N.,Madadi, M., Ostovar,B., Dongare, P. D., McCarthy,L.A., Chiang, W.Y., Chang, W.S.,Halas,N.J., Landes C. F.,Sader, J.E., Link,S., "Strong Substrate Binding Modulates the Acoustic Quality Factors in Gold Nanodisks J. Phys. Chem. C 2023, 127, 10, 5054–5066 (2023)

Al-Zubeidi, A.,Ostovar, B., Carlin, C.C., Cam Li,B., Lee, S.A., Chiayng,W.Y., Gross, N., Dutta, S., Misiura, A., Searles, E.K., Chakraborty, A., Roberts, S.T., Dionne, J.A., Rossky, P.J., Landes C. F., Link,S., "Mechanism for plasmon-generated solvated electrons Proceedings of the National Academy of Sciences of the United States of America. , 2023, Vol.120(3), p.e2217035120 (2023)

Searles, E.K., Gomez, E., Lee,S.A., Ostovar, B., Link, S., Landes C. F., "Single-Particle Photoluminescence and Dark-Field Scattering during Charge Density Tuning J. Phys. Chem. Lett. 2023, 14, 2, 318–325 (2023)

Dutta, C.,Misiura, A., Bishop, L. D. C., Marciel, Amanda B., Kisley,L., Landes C. F., "Toward Protein Chromatography by Design: Stochastic Theory, Single-Molecule Parameter Control, and Stimuli-Responsive Materials J. Phys. Chem. C 2022, 126, 44, 18587–18595 (2022)

Lee A, S., Ostovar, B.,Landes, C. F., Link S., "Spectroscopic signatures of plasmon-induced charge transfer in gold nanorods J. Chem. Phys. 156, 064702 (2022)

Warning A, L., Miandashti, A R., Misiura, A., Landes, C. F., Link S., "Naturally Occurring Proteins Direct Chiral Nanorod Aggregation J. Phys. Chem. C 2022

Rice University
Chemistry Department
Smalley-Curl Institute
ECE Department
LaNSIR
IBB
NDSEG
NSF
NIH
Rice
Welch