Research Areas

Quantifying heterogeneous structure-function relationships one molecule at a time presents challenges for theory, experiment, and data analysis. We must develop new methods to collect, process, and understand super-resolved spectroscopic data to respond to the challenges of today's scientific problems. As such, our research focuses on three linked objectives:

  • Develop new spectroscopic data acquisition and analysis methods to image dynamics at nanoscale interfaces
  • Define testable hypotheses for protein separations by combining super-resolved protein adsorption and a stochastic theory of ion-exchange chromatography
  • Design methods to control photocatalysis at nanoparticle interfaces with the ultimate goal of controlling single electron transfer
Predictive Separations

Predictive Separations

Spectro-electrochemistry

Spectro-electrochemistry

Protein Dynamics at Interfaces

Protein Dynamics at Interfaces

Imaging and Signal Processing

Imaging and Signal Processing

Single-Molecule Spectroscopy

Single-Molecule Spectroscopy

Hoener, B.S., Kirchner, S.R., Heiderscheit, T.S., Collins, S.S.E., Chang, W., Link, S., Landes, C.F., "Plasmonic Sensing and Control of Single-Nanoparticle Electrochemistry Chem. 2018, 4:7, 1560-1585

Moringo, N.A., Shen, H., Bishop, L.D.C., Wang, W., Landes, C.F., "Enhancing Analytical Separations Using Super-Resolution Microscopy Annu. Rev. Phys. Chem. 2018, 69:14, 1-14.23

Dolino, D.M., Chatterjee, S., MacLean, D.M., Flatebo, C., Bishop, L.D.C., Shaikh, S.A., Landes, C.F., Jayaraman, V., "The structure–energy landscape of NMDA receptor gating Nat. Chem. Bio., 2017, 13, pp. 1232-1238

Kisley, L., Ujwal, P., Dhamane, S., Kourentzi, K., Tauzin, L.J., Wilson, R.C., Landes, C.F., "Competitive multicomponent anion exchange adsorption of proteins at the single molecule level Analyst, 2017, 17(142), pp 3127-3131

Moringo, N.A., Shen, H., Tauzin, L.J., Wang, W., Bishop, L.D.C., Landes, C.F., "Variable Lysozyme Transport Dynamics on Oxidatively Functionalized Polystyrene Films Langmuir, 2017, 33(41), pp 10818-10828

Hoener, B. S., Zhang, H., Heiderscheit, T.S., Kirchmer, S.R., Indrasekara, A.S.D.S., Baiyasi, R., Cai, Y., Nordlander, P., Link, S., Landes, C. F., and Chang, W., "Spectral Response of Plasmonic Gold Nanoparticles to Capacitive Charging: Morphology Effects J. Phys Chem Lett., 2017, 8 (12), pp 2681–2688

Shen, H, Tauzin, L, Baiyasi, R, Wang, W, Moringo, N, Shuang, B, and Landes, C. F, "Single Particle Tracking: From Theory to Biophysical Applications Chem. Rev., 2017 117 (11), pp 7331–7376

Indrasekara, A.S.D.S., Shuang, B., Hollenhorst, F., Hoener, B.S., Hoggard, A., Chen, S., Villarreal, E., Cai, Y., Kisley L., Derry, P. J., Chang, W., Zubarev, E. R., Ringe, E., Link, S., and Landes, C. F., "Optimization of Spectral and Spatial Conditions to Improve Super-Resolution Imaging of Plasmonic Nanoparticles J. Phys. Chem. Lett, 2017 8 (1), pp 299–306

Hoener, B.S.; Byers, C.P.; Indrasekara, S.; Hoggard, A.; Chang, W.S.; Link, S.; Landes, C. F., "Spectroelectrochemistry of Halide Anion Adsorption and Dissolution of Single Gold Nanorods J. Phys. Chem. C, 2016, 120 (37), pp 20604–20612

Rice University
Chemistry Department
Smalley-Curl Institute
ECE Department
LaNSIR
IBB
NDSEG
NSF
NIH
Rice
Welch