The Landes Research Group at Rice University

The Landes Research Group develops new spectroscopic tools to image chemical dynamics at interfaces at the limit of a single event. Using this super-resolved chemical knowledge, we create new models to understand and predict macroscale processes like protein separation and photocatalysis.


Ensemble vs. Single Molecule

A wide range of biological and materials processes rely on nanoscale interfacial dynamics. Single molecule methods allow us to identify the chemical complexity of these interactions by revealing the underlying populations that form the ensemble measurement. In doing so, we can identify and tune the rare chemical populations that play a crucial role in reactivity.

Towards Predictive Separations

The cost of bringing a new protein based therapeutic to market averages ~$2.6 billion dollars, of which 50% can be dedicated to isolating and purifying the active compound. A primary contributor to the cost is the empirical optimization of chromatographic separation. Our lab seeks to understand separations from the scale of individual analytes, with a goal to create a new predictive model of chromatography to eliminate the need for costly empirical methods.


Breaking the Abbe-Diffraction Limit

The Abbe diffraction limit sets a lower bound of a few hundred nanometers for the size of objects we can observe with traditional optical microscopy. This limit is defined by light’s wavelength. Our lab develops new mathematical methods to break the Abbe diffraction limit and achieve spatial resolutions of just a few nanometers and time resolutions faster than traditional cameras frame times.

New Postdoctoral Scholar   11/04/2023

Nikita Kovalenko

We are happy to welcome our new Postdoctoral Researcher Nikita Kovalenko We look forward to your future successes in this group!

The Landes research group V2.0   09/06/2023

Find us at UIUC

The Landes Research Group is at Midwest!

Departmental Achievement Awards   08/06/2023

Jagriti ChatterjeeZhenyang Jia

Congratulations to JagritiChatterjee, Zhenyang Jia for winning the Gold and Silver Awards respectively at 9th SCI colloquium poster session.Keep up the good work!

Congratulations.   06/20/2023

Zhenyang Jia

Congratulations Zhenyang Jia on passing your Qualifying exam! Best wishes for your future work!

Predictive Separations

Predictive Separations



Protein Dynamics at Interfaces

Protein Dynamics at Interfaces

Imaging and Signal Processing

Imaging and Signal Processing

Single-Molecule Spectroscopy

Single-Molecule Spectroscopy

Gross, N., Wang, W., Brasel, S.,Searles, E.K, Bourgeois,B.,Dionne, J.A.,Landes, C. F., Link,S., "High-Throughput Screening of Optical Properties of Glass-Supported Plasmonic Nanoparticles Fabricated by Polymer Pen Lithography" J. Phys. Chem. C 2023, 127, 39, 19607–19619

Jones, A.,Searles, E.K, Mayer,M.,Hoffmann, M., Gross, N., Oh, H., Fery, A., Link,S.,Landes, C. F., "Active Control of Energy Transfer in Plasmonic Nanorod–Polyaniline Hybrids " J. Phys. Chem. Lett. 2023, 14, 36, 8235–8243

Oh, H.,Searles, E.K, Chatterjee,S.,Jia, Z., Lee, S.A., Link,S.,Landes, C. F., "Plasmon Energy Transfer Driven by Electrochemical Tuning of Methylene Blue on Single Gold Nanorods " ACS Nano 2023, 17, 18, 18280–18289

Gross, N.,Kuhs, C.T, Ostovar,B.,Chiang, W.Y., Wilson, K.S., Volek,T.S., Faitz,Z.M., Carlin, C.C., Dionne, J.A., Zanni, M.T., Gruebele,M., Roberts,S.T., Link,S.,Landes, C. F., "Progress and Prospects in Optical Ultrafast Microscopy in the Visible Spectral Region: Transient Absorption and Two Dimensional Microscopy " J. Phys. Chem. C 2023, 127, 30, 14557–14586

Duan, H., Jia,Z., Liaqat, M. ,Mellor, M.D., Tan,H., Nieh, M.P., Lin, Y., Link, S., Landes, C. F., He,J., "Site-Specific Chemistry on Gold Nanorods: Curvature-Guided Surface Dewetting and Supracolloidal Polymerization" ACS Nano 2023 (2023)

Fan, D.,Bajgiran,R.S.,Samghabadi,S.F. ,Dutta, C., Gillett,E., Rossky, P.J., Conrad, J.C., Marciel, B.A., Landes, C. F., "Imaging Heterogeneous 3D Dynamics of Individual Solutes in a Polyelectrolyte Brush" Langmuir 2023, 39, 24, 8532–8539 (2023)

Rice University
Chemistry Department
Smalley-Curl Institute
ECE Department