The Landes Research Group at Rice University

The Landes Research Group develops new spectroscopic tools to image chemical dynamics at interfaces at the limit of a single event. Using this super-resolved chemical knowledge, we create new models to understand and predict macroscale processes like protein separation and photocatalysis.


Ensemble vs. Single Molecule

A wide range of biological and materials processes rely on nanoscale interfacial dynamics. Single molecule methods allow us to identify the chemical complexity of these interactions by revealing the underlying populations that form the ensemble measurement. In doing so, we can identify and tune the rare chemical populations that play a crucial role in reactivity.

Towards Predictive Separations

The cost of bringing a new protein based therapeutic to market averages ~$2.6 billion dollars, of which 50% can be dedicated to isolating and purifying the active compound. A primary contributor to the cost is the empirical optimization of chromatographic separation. Our lab seeks to understand separations from the scale of individual analytes, with a goal to create a new predictive model of chromatography to eliminate the need for costly empirical methods.


Breaking the Abbe-Diffraction Limit

The Abbe diffraction limit sets a lower bound of a few hundred nanometers for the size of objects we can observe with traditional optical microscopy. This limit is defined by light’s wavelength. Our lab develops new mathematical methods to break the Abbe diffraction limit and achieve spatial resolutions of just a few nanometers and time resolutions faster than traditional cameras frame times.

Departmental Achievement Awards   04/28/2023


Congratulations to Selena Zermeño for winning this year's School of Natural Sciences winner of the Staff Service Award!!!, You deserve every success!

Congratulations   04/04/2023

Emily Searles

Congratulations, Emily Searles, on your Ph.D. defense. We will miss you ! Good luck with the coming future!

Congratulations.   03/31/2023

Jagriti ChatterjeeEmil GillettJiamu Lin

Congratulations Jagriti Chatterjee, Emil Gillett and Jiamu Lin on passing your Qualifying Exam. Good luck on the years to come!

New Postdoctoral Scholar   11/10/2022

Jeladhara Shobhanan

We are happy to welcome our new Postdoctoral Researcher Jeladhara Shobhanan We look forward to your accomplishments in this group!

Predictive Separations

Predictive Separations



Protein Dynamics at Interfaces

Protein Dynamics at Interfaces

Imaging and Signal Processing

Imaging and Signal Processing

Single-Molecule Spectroscopy

Single-Molecule Spectroscopy

Wallum,A.,Liu,Z.,Lee,J.,Chatterjee, S., Tauzin,L., Barr, C.D., Brown,A., Landes C. F., Nicely, A.L., Gruebele, M., "An Instrument Assembly and Data Science Lab for Early Undergraduate Education" J. Chem. Educ. 2023 (2023)

Lee, S.A.,Kuhs, C.T., Searles,E.K.,Everitt, H.O., Link,S., Landes C. F., "d-Band Hole Dynamics in Gold Nanoparticles Measured with Time-Resolved Emission Upconversion Microscopy" Nano Lett. 2023, 23, 8, 3501–3506 (2023)

Gross, N.,Madadi, M., Ostovar,B., Dongare, P. D., McCarthy,L.A., Chiang, W.Y., Chang, W.S.,Halas,N.J., Landes C. F.,Sader, J.E., Link,S., "Strong Substrate Binding Modulates the Acoustic Quality Factors in Gold Nanodisks" J. Phys. Chem. C 2023, 127, 10, 5054–5066 (2023)

Al-Zubeidi, A.,Ostovar, B., Carlin, C.C., Cam Li,B., Lee, S.A., Chiayng,W.Y., Gross, N., Dutta, S., Misiura, A., Searles, E.K., Chakraborty, A., Roberts, S.T., Dionne, J.A., Rossky, P.J., Landes C. F., Link,S., "Mechanism for plasmon-generated solvated electrons" Proceedings of the National Academy of Sciences of the United States of America. , 2023, Vol.120(3), p.e2217035120 (2023)

Searles, E.K., Gomez, E., Lee,S.A., Ostovar, B., Link, S., Landes C. F., "Single-Particle Photoluminescence and Dark-Field Scattering during Charge Density Tuning" J. Phys. Chem. Lett. 2023, 14, 2, 318–325 (2023)

Dutta, C.,Misiura, A., Bishop, L. D. C., Marciel, Amanda B., Kisley,L., Landes C. F., "Toward Protein Chromatography by Design: Stochastic Theory, Single-Molecule Parameter Control, and Stimuli-Responsive Materials" J. Phys. Chem. C 2022, 126, 44, 18587–18595 (2022)

Rice University
Chemistry Department
Smalley-Curl Institute
ECE Department