The Landes Research Group at Rice University

The Landes Research Group develops new spectroscopic tools to image chemical dynamics at interfaces at the limit of a single event. Using this super-resolved chemical knowledge, we create new models to understand and predict macroscale processes like protein separation and photocatalysis.


Ensemble vs. Single Molecule

A wide range of biological and materials processes rely on nanoscale interfacial dynamics. Single molecule methods allow us to identify the chemical complexity of these interactions by revealing the underlying populations that form the ensemble measurement. In doing so, we can identify and tune the rare chemical populations that play a crucial role in reactivity.

Towards Predictive Separations

The cost of bringing a new protein based therapeutic to market averages ~$2.6 billion dollars, of which 50% can be dedicated to isolating and purifying the active compound. A primary contributor to the cost is the empirical optimization of chromatographic separation. Our lab seeks to understand separations from the scale of individual analytes, with a goal to create a new predictive model of chromatography to eliminate the need for costly empirical methods.


Breaking the Abbe-Diffraction Limit

The Abbe diffraction limit sets a lower bound of a few hundred nanometers for the size of objects we can observe with traditional optical microscopy. This limit is defined by light’s wavelength. Our lab develops new mathematical methods to break the Abbe diffraction limit and achieve spatial resolutions of just a few nanometers and time resolutions faster than traditional cameras frame times.

New Postdoctoral Scholar   11/10/2022

Jeladhara Shobhanan

We are happy to welcome our new Postdoctoral Researcher Jeladhara Shobhanan We look forward to your accomplishments in this group!

Welcome!   09/15/2022

Dr. Zhe QiangSara Valdez

The Landes Research Group welcomes our Visting Scientist Dr. Zhe Qiang (Asst. Prof at University of Southern Mississippi) and Visiting Student , Sara Valdez We are glad you are here!

Thank you Summer Interns   08/07/2022

Dr. Shawna LeeJohn FergusonMalaysia Moses

Thank you Dr. Shawna Lee , John Ferguson and Malaysia Moses for joining us this summer! We had a great time having you all and best wishes for your future endeavors

Departmental Achievement Awards   08/06/2022

Jagriti Chatterjee

Congratulations to JagritiChatterjee for winning the Silver Award at 8th SCI colloquium poster session.Keep up the good work!

Predictive Separations

Predictive Separations



Protein Dynamics at Interfaces

Protein Dynamics at Interfaces

Imaging and Signal Processing

Imaging and Signal Processing

Single-Molecule Spectroscopy

Single-Molecule Spectroscopy

Dutta, C.,Misiura, A., Bishop, L. D. C., Marciel, Amanda B., Kisley,L., Landes C. F., "Toward Protein Chromatography by Design: Stochastic Theory, Single-Molecule Parameter Control, and Stimuli-Responsive Materials" J. Phys. Chem. C 2022, 126, 44, 18587–18595

Lee A, S., Ostovar, B.,Landes, C. F., Link S., "Spectroscopic signatures of plasmon-induced charge transfer in gold nanorods" J. Chem. Phys. 156, 064702 (2022)

Warning A, L., Miandashti, A R., Misiura, A., Landes, C. F., Link S., "Naturally Occurring Proteins Direct Chiral Nanorod Aggregation" J. Phys. Chem. C 2022

Shiratori, K., Bishop, L. D. C., Ostovar, B., Baiyasi, R., Cai, Y., Rossky, P. J., Landes, C. F., Link, S., "Machine-Learned Decision Trees for Predicting Gold Nanorod Sizes from Spectra" J. Phys. Chem. C 2021, 125, 35, 19353–19361

Rice University
Chemistry Department
Smalley-Curl Institute
ECE Department