The Landes Research Group at Rice University

The Landes Research Group develops new spectroscopic tools to image chemical dynamics at interfaces at the limit of a single event. Using this super-resolved chemical knowledge, we create new models to understand and predict macroscale processes like protein separation and photocatalysis.


Ensemble vs. Single Molecule

A wide range of biological and materials processes rely on nanoscale interfacial dynamics. Single molecule methods allow us to identify the chemical complexity of these interactions by revealing the underlying populations that form the ensemble measurement. In doing so, we can identify and tune the rare chemical populations that play a crucial role in reactivity.

Towards Predictive Separations

The cost of bringing a new protein based therapeutic to market averages ~$2.6 billion dollars, of which 50% can be dedicated to isolating and purifying the active compound. A primary contributor to the cost is the empirical optimization of chromatographic separation. Our lab seeks to understand separations from the scale of individual analytes, with a goal to create a new predictive model of chromatography to eliminate the need for costly empirical methods.


Breaking the Abbe-Diffraction Limit

The Abbe diffraction limit sets a lower bound of a few hundred nanometers for the size of objects we can observe with traditional optical microscopy. This limit is defined by light’s wavelength. Our lab develops new mathematical methods to break the Abbe diffraction limit and achieve spatial resolutions of just a few nanometers and time resolutions faster than traditional cameras frame times.

Quals Passed   04/11/2019

Anastasiia Misiura

Congratulations to Anastasiia Misiura for passing her Qualifying Exam this week. We look forward to your accomplishments in the coming years.

Ph.D.   04/09/2019

Sudeshna Chatterjee

Congratulations to Sudeshna Chatterjee for passing her Thesis defense. Good luck in Portland Sudeshna!

In the news...   02/14/2019

Wenxiao WangNicholas MoringoChayan Dutta

Congratulations to Wenxiao Wang, Nicholas Moringo, and Chayan Dutta for getting their newest publication featured in the press!

New Postdoctoral Scholar   01/07/2019

Min Zhou

We are happy to welcome our new Postdoctoral Researcher Min Zhou to the LRG Offices. What a great way to ring in the New Year!

Predictive Separations

Predictive Separations



Protein Dynamics at Interfaces

Protein Dynamics at Interfaces

Imaging and Signal Processing

Imaging and Signal Processing

Single-Molecule Spectroscopy

Single-Molecule Spectroscopy

Baiyasi, R, Jebeli, S.A.H., Zhang, Q., Su, L.,Hofkens, J., Uji-i, H., Link, S., Landes, C.F., "PSF Distortion in Dye-Plasmonic Nanomaterial Interactions: Friend or Foe?" ACS Photonics 2019, 6(3), pp. 699-708

Wang, W., Ye, F., Shen, H., Moringo, N.A., Dutta, C., Robinson, J.T., Landes, C.F., "Generalized method to design phase masks for 3D super-resolution microscopy" Opt. Express 2019, 27(3), pp. 3799-3816

Chatterjee, S., A., Carina, Nurik, C.E., Carrejo, N.C., Dutta, D., Jayaraman, V., Landes, C.F., "Phosphorylation Induces Conformational Rigidity at the C-Terminal Domain of AMPA Receptors" J. Phys. Chem. B 2019

Al-Zubeidi, A., Hoener, B.S., Collins, S.S.E., Wang, W., Kirchner, S.R., Jebeli, S.A.H, Joplin, A., Chang, W-S., Link, S., Landes, C.F., "Hot Holes Assist Plasmonic Nanoelectrode Dissolution" Nano Lett. 2019

Hoener, B.S., Kirchner, S.R., Heiderscheit, T.S., Collins, S.S.E., Chang, W., Link, S., Landes, C.F., "Plasmonic Sensing and Control of Single-Nanoparticle Electrochemistry" Chem. 2018, 4:7, 1560-1585

Rice University
Chemistry Department
Smalley-Curl Institute
ECE Department