We pair our experimental endeavors with statistically driven theory to explain our results as well as create methods that allow us to break past the Abbe-Diffraction limit. In general, we attempt to utilize new techniques originating from the fields of electrical engineering and computer science to tease subtle information observed under the microscope. In doing so, we can capture details about the conformational state of proteins, particle locations below the diffraction limit of light, and capture dynamics occurring below the framerate of our detector.
Dominguez-Medina, S.; Chen, S.; Blankenburg, J.; Swanglap, P.; Landes, C. F.; Link, S, "Measuring the Hydrodynamic Size of Nanoparticles Using Fluctuation Correlation Spectroscopy" Ann. Rev. Phys. Chem. 2016, 67.
Kisley, L.; Brunetti, R.; Tauzin, L. J.; Shuang, B.; Yi, X.; Kirkeminde, A. W.; Higgins, D. A.; Weiss, S; Landes, C.F., "Characterization of Porous Materials by Fluorescence Correlation Spectroscopy Super-resolution Optical Fluctuation Imaging" ACS Nano, 2015, 9, 9158–9166.