Research Areas

Quantifying heterogeneous structure-function relationships one molecule at a time presents challenges for theory, experiment, and data analysis. We must develop new methods to collect, process, and understand super-resolved spectroscopic data to respond to the challenges of today's scientific problems. As such, our research focuses on three linked objectives:

  • Develop new spectroscopic data acquisition and analysis methods to image dynamics at nanoscale interfaces
  • Define testable hypotheses for protein separations by combining super-resolved protein adsorption and a stochastic theory of ion-exchange chromatography
  • Design methods to control photocatalysis at nanoparticle interfaces with the ultimate goal of controlling single electron transfer
Predictive Separations

Predictive Separations

Spectro-electrochemistry

Spectro-electrochemistry

Protein Dynamics at Interfaces

Protein Dynamics at Interfaces

Imaging and Signal Processing

Imaging and Signal Processing

Single-Molecule Spectroscopy

Single-Molecule Spectroscopy

Shiratori, K., Bishop, L. D. C., Ostovar, B., Baiyasi, R., Cai, Y., Rossky, P. J., Landes, C. F., Link, S., "Machine-Learned Decision Trees for Predicting Gold Nanorod Sizes from Spectra J. Phys. Chem. C 2021

Misiura, A., Shen, H., Tauzin, L., Dutta, C., Bishop, L. D. C., Carrejo, N. C., Zepeda O, J., Ramezani, S., Moringo, N. A., Marciel, A. B., Rossky, P. J., Landes, C. F., "Single-Molecule Dynamics Reflect IgG Conformational Changes Associated with Ion-Exchange Chromatography Anal. Chem. 2021

Al-Zubeidi, A., Stein, F., Flatebo, C., Rehbock, C., Hosseini Jebeli, S. A., Landes, C. F., Barcikowski, S., Link, S.,, "Single-Particle Hyperspectral Imaging Reveals Kinetics of Silver Ion Leaching from Alloy Nanoparticles ACS Nano 2021

Baiyasi, R., Goldwyn, H. J., McCarthy, L. A., West, C. A., Hosseini Jebeli, S. A., Masiello, D. J., Link, S., Landes, C. F., "Coupled-Dipole Modeling and Experimental Characterization of Geometry-Dependent Trochoidal Dichroism in Nanorod Trimers ACS Photonics 2021, 8, 4, 1159–1168

Heiderscheit, T. S., Oikawa, S., Sanders, S., Minamimoto, H., Searles, E. K., Landes, C. F., Murakoshi, K., Manjavacas, A., Link, S., "Tuning Electrogenerated Chemiluminescence Intensity Enhancement Using Hexagonal Lattice Arrays of Gold Nanodisks J. Phys. Chem. Lett. 2021, 2516-2522

Collins, S. S. E., Searles, E. K., Tauzin, L. J., Lou, M., Bursi, L., Liu, Y., Song, J., Flatebo, C., Baiyasi, R., Cai, Y. Y., Foerster, B., Lian, T., Nordlander, P., Link, S., Landes, C. F., "Plasmon Energy Transfer in Hybrid Nanoantennas ACS Nano 2020

Calabrase, W., Bishop, L. D. C., Dutta, C., Misiura, A., Landes, C. F., Kisley, L., "Transforming Separation Science with Single-Molecule Methods Anal. Chem. 2020, 92, 20, 13622-13629

Rice University
Chemistry Department
Smalley-Curl Institute
ECE Department
LaNSIR
IBB
NDSEG
NSF
NIH
Rice
Welch