Quantifying heterogeneous structure-function relationships one molecule at a time presents challenges for theory, experiment, and data analysis. We must develop new methods to collect, process, and understand super-resolved spectroscopic data to respond to the challenges of today's scientific problems. As such, our research focuses on three linked objectives:
Dutta, C.,Misiura, A., Bishop, L. D. C., Marciel, Amanda B., Kisley,L., Landes C. F., "Toward Protein Chromatography by Design: Stochastic Theory, Single-Molecule Parameter Control, and Stimuli-Responsive Materials J. Phys. Chem. C 2022, 126, 44, 18587–18595
Misiura, A.,Dutta, C., Leung W.,Zepeda O,J., Terlier T., Landes C. F., "The competing influence of surface roughness, hydrophobicity, and electrostatics on protein dynamics on a self-assembled monolayer J. Chem. Phys. 156, 094707 (2022)
Lee A, S., Ostovar, B.,Landes, C. F., Link S., "Spectroscopic signatures of plasmon-induced charge transfer in gold nanorods J. Chem. Phys. 156, 064702 (2022)
Warning A, L., Miandashti, A R., Misiura, A., Landes, C. F., Link S., "Naturally Occurring Proteins Direct Chiral Nanorod Aggregation J. Phys. Chem. C 2022
Zepeda O, J., Bishop, L. D. C., Dutta, C., Sarkar-Banerjee, S., Leung, W. W., Landes, C. F., "Untying the Gordian KNOT: Unbiased Single Particle Tracking Using Point Clouds and Adaptive Motion Analysis J. Phys. Chem. A 2021
Shiratori, K., Bishop, L. D. C., Ostovar, B., Baiyasi, R., Cai, Y., Rossky, P. J., Landes, C. F., Link, S., "Machine-Learned Decision Trees for Predicting Gold Nanorod Sizes from Spectra J. Phys. Chem. C 2021, 125, 35, 19353–19361
Flatebo, C., Dutta, C., Ostovar, B., Link, S., Landes, C. F., "Heterogeneity and Hysteresis in the Polymer Collapse of Single Core–Shell Stimuli-Responsive Plasmonic Nanohybrids J. Phys. Chem. C 2021, 125, 33, 18270–18278
Misiura, A., Shen, H., Tauzin, L., Dutta, C., Bishop, L. D. C., Carrejo, N. C., Zepeda O, J., Ramezani, S., Moringo, N. A., Marciel, A. B., Rossky, P. J., Landes, C. F., "Single-Molecule Dynamics Reflect IgG Conformational Changes Associated with Ion-Exchange Chromatography Anal. Chem. 2021, 93, 32, 11200–11207
Al-Zubeidi, A., Stein, F., Flatebo, C., Rehbock, C., Hosseini Jebeli, S. A., Landes, C. F., Barcikowski, S., Link, S.,, "Single-Particle Hyperspectral Imaging Reveals Kinetics of Silver Ion Leaching from Alloy Nanoparticles ACS Nano 2021, 15, 5, 8363–8375
Baiyasi, R., Goldwyn, H. J., McCarthy, L. A., West, C. A., Hosseini Jebeli, S. A., Masiello, D. J., Link, S., Landes, C. F., "Coupled-Dipole Modeling and Experimental Characterization of Geometry-Dependent Trochoidal Dichroism in Nanorod Trimers ACS Photonics 2021, 8, 4, 1159–1168