The Landes Research Group at Rice University


The Landes Research Group develops new spectroscopic tools to image chemical dynamics at interfaces at the limit of a single event. Using this super-resolved chemical knowledge, we create new models to understand and predict macroscale processes like protein separation and photocatalysis.


 

Ensemble vs. Single Molecule

A wide range of biological and materials processes rely on nanoscale interfacial dynamics. Single molecule methods allow us to identify the chemical complexity of these interactions by revealing the underlying populations that form the ensemble measurement. In doing so, we can identify and tune the rare chemical populations that play a crucial role in reactivity.

Towards Predictive Separations

The cost of bringing a new protein based therapeutic to market averages ~$2.6 billion dollars, of which 50% can be dedicated to isolating and purifying the active compound. A primary contributor to the cost is the empirical optimization of chromatographic separation. Our lab seeks to understand separations from the scale of individual analytes, with a goal to create a new predictive model of chromatography to eliminate the need for costly empirical methods.

 

Breaking the Abbe-Diffraction Limit

The Abbe diffraction limit sets a lower bound of a few hundred nanometers for the size of objects we can observe with traditional optical microscopy. This limit is defined by light’s wavelength. Our lab develops new mathematical methods to break the Abbe diffraction limit and achieve spatial resolutions of just a few nanometers and time resolutions faster than traditional cameras frame times.

Welcome   01/28/2020

Dongyu FanWesley Leung

The LRG welcomes in two new members, Dongyu Fan and Wesley Leung. Good luck you two!

Congratulations   12/12/2019

Nicholas Moringo

Congratulations to Nicholas Moringo for completing his Ph.D. studies. We know you are bound for great things but will miss your input. Good luck!

Congratulations   08/09/2019

Nicholas Moringo

Congratulations to Nicholas Moringo for winning the Army Futures Presentation Award at the 5th Annual SCI Summer Research Symposium!

Lab Outing   08/06/2019

Landes group

The Super Group returned to Minute Maid Stadium for our yearly Astros Game. Go 'Stros!

Predictive Separations

Predictive Separations

Spectro-electrochemistry

Spectro-electrochemistry

Protein Dynamics at Interfaces

Protein Dynamics at Interfaces

Imaging and Signal Processing

Imaging and Signal Processing

Single-Molecule Spectroscopy

Single-Molecule Spectroscopy

Moringo, N.A., Bishop, L.D.C., Shen, H., Misiura, A., Carrejo, N.C., Baiyasi, R., Wang, W., Ye, F., Robinson, J.T., Landes C.F., "A mechanistic examination of salting out in protein-polymer membrane interactions" PNAS 2019, 116(46) 22938-22945.

Zhang, Q., Hernandez, T., Smith, K.W., Jebeli, S.A.H., Dai, A.X., Warning, L., Baiyasi, R., McCarthy, L.A., Guo, H., Chen, D-H, Dionne, J.A., Landes C.F., Link, S., "Unraveling the origin of chirality from plasmonic nanoparticle-protein complexes" Science 2019, 365, 6460, 1475-1478

Cai, Y., Collins, S.S.E., Gallagher, M.J., Bhattacharjee, U., Zhang, R., Chow, T.H., Ahmadivand, A., Ostovar, B., Al-Zubeidi, A., Wnag, Jianfang, Nordlander, P., Landes, C.F., Link, S., "Single Particle emission spectroscopy resolves d-hole relaxation in copper nanocubes" ACS Energy lett. 2019, 4, 10, 2458-2465

Heiderscheit, T.S., Gallagher, M.J., Baiyasi, R., Collins, S.S.E., Jebeli, S.A.H., Scarabelli, L., Zl-Zubeidi, A., Flatebo, C., Chang, W-S., Landes, C.F., Link, S., "Nanoelectrode-emitter spectral overlap amplifies surface enhanced electrogenerated chemiluminescence" J. Chem. Phys. 151, 144712 (2019)

Rice University
Chemistry Department
Smalley-Curl Institute
ECE Department
LaNSIR
IBB