The Landes Research Group at Rice University

The Landes Research Group develops new spectroscopic tools to image chemical dynamics at interfaces at the limit of a single event. Using this super-resolved chemical knowledge, we create new models to understand and predict macroscale processes like protein separation and photocatalysis.


Ensemble vs. Single Molecule

A wide range of biological and materials processes rely on nanoscale interfacial dynamics. Single molecule methods allow us to identify the chemical complexity of these interactions by revealing the underlying populations that form the ensemble measurement. In doing so, we can identify and tune the rare chemical populations that play a crucial role in reactivity.

Towards Predictive Separations

The cost of bringing a new protein based therapeutic to market averages ~$2.6 billion dollars, of which 50% can be dedicated to isolating and purifying the active compound. A primary contributor to the cost is the empirical optimization of chromatographic separation. Our lab seeks to understand separations from the scale of individual analytes, with a goal to create a new predictive model of chromatography to eliminate the need for costly empirical methods.


Breaking the Abbe-Diffraction Limit

The Abbe diffraction limit sets a lower bound of a few hundred nanometers for the size of objects we can observe with traditional optical microscopy. This limit is defined by light’s wavelength. Our lab develops new mathematical methods to break the Abbe diffraction limit and achieve spatial resolutions of just a few nanometers and time resolutions faster than traditional cameras frame times.

Promotion   04/27/2020

Jixin Chen

Congratulations to Landes Group Alum Prof. Jixin Chen for receiving tenure at Ohio University!

Promotion   04/02/2020

Charlisa Daniels

Congratulations to Landes Group Alum Prof. Charlisa Daniels for receiving tenure at Northern Kentucky University. We are proud of all you have accomplished and are excited to see what the future holds in store for you!

In the news...   02/25/2020

Landes group

Christy Landes has been featured in ACS Energy Letter's Women Scientists at the Forefront of Energy Research virtual feature!

Congratulations   02/14/2020

Charlotte FlateboEmily Searles

Congratulations to Charlotte Flatebo, Lauren McCarthy, Emily Searles, Lauren Warning for winning presentation awards at the Smalley-Curl Spring Symposium!

Predictive Separations

Predictive Separations



Protein Dynamics at Interfaces

Protein Dynamics at Interfaces

Imaging and Signal Processing

Imaging and Signal Processing

Single-Molecule Spectroscopy

Single-Molecule Spectroscopy

Baiyasi, R., Gallagher, M.J., McCarthy, L.A., Searles, E.K., Zhaing, Q., Link, S., Landes, C.F., "Quantitative Analysis of Nanorod Aggregation and Morphology from Scanning Electron Micrographs Using SEMseg" J. Phys. Chem. A 2020

Dutta, C., Bishop, L.D.C, Zepeda O, J., Chatterjee, S., Flatebo, C., Landes, C.F., "Imaging Switchable Protien Interactions With an Active Porous Polymer Support" J. Phys. Chem. B 2020, 124, 22, 4412-4420.

Ostovar, B., Su, M.N., Renard, D., Clark, B.D., Dongare, P.D., Dutta, C., Gross, N., Sader, J.E., Landes, C.F., Chang, W-S, Halas, N.J., Link, S., "Acoustic Vibrations of Al Nanocrystals: Size, Shape, and Crystallinity Revealed by Single-Particle Transient Extinction Spectroscopy" J. Phys. Chem. A 2020, 124, 19, 3924-3934.

Warning, L.A., Zhang, Q., Baiyasi, R., Landes, C.F., Link, S., "Nanoscale Surface-induced Unfolding of Single Fibronectin is Restricted by Serum Albumin Crowding" JPCL 2020, 11, 3, 1170-1177.

Rice University
Chemistry Department
Smalley-Curl Institute
ECE Department