The Landes Research Group at Rice University

The Landes Research Group develops new spectroscopic tools to image chemical dynamics at interfaces at the limit of a single event. Using this super-resolved chemical knowledge, we create new models to understand and predict macroscale processes like protein separation and photocatalysis.


Ensemble vs. Single Molecule

A wide range of biological and materials processes rely on nanoscale interfacial dynamics. Single molecule methods allow us to identify the chemical complexity of these interactions by revealing the underlying populations that form the ensemble measurement. In doing so, we can identify and tune the rare chemical populations that play a crucial role in reactivity.

Towards Predictive Separations

The cost of bringing a new protein based therapeutic to market averages ~$2.6 billion dollars, of which 50% can be dedicated to isolating and purifying the active compound. A primary contributor to the cost is the empirical optimization of chromatographic separation. Our lab seeks to understand separations from the scale of individual analytes, with a goal to create a new predictive model of chromatography to eliminate the need for costly empirical methods.


Breaking the Abbe-Diffraction Limit

The Abbe diffraction limit sets a lower bound of a few hundred nanometers for the size of objects we can observe with traditional optical microscopy. This limit is defined by light’s wavelength. Our lab develops new mathematical methods to break the Abbe diffraction limit and achieve spatial resolutions of just a few nanometers and time resolutions faster than traditional cameras frame times.

Congratulations   10/06/2021

Rashad Baiyasi

Dr. Rashad Baiyasi is working as a Senior Data Scientist at Sandia National Labs now. Congratulations to your new dream job!

Fellowship   10/04/2021

Hyuncheol Oh

We are happy to welcome our new Postdoctoral Researcher Hyuncheol Oh who is supported by the Postdoctoral Fellowship from the National Research Foundation of Korea! We look forward to your future successes!

New Undergraduate Researcher   08/05/2021

Annette Jones

The LRG welcomes our new undergraduate researcher Annette Jones! Good luck!

In the news...   08/03/2021

Christy Landes

A multiuniversity team led by Christy Landes has landed a National Science Foundation grant to establish the NSF Phase 1 Center for Adapting Flaws into Features. Read more from Rice News here.

Predictive Separations

Predictive Separations



Protein Dynamics at Interfaces

Protein Dynamics at Interfaces

Imaging and Signal Processing

Imaging and Signal Processing

Single-Molecule Spectroscopy

Single-Molecule Spectroscopy

Shiratori, K., Bishop, L. D. C., Ostovar, B., Baiyasi, R., Cai, Y., Rossky, P. J., Landes, C. F., Link, S., "Machine-Learned Decision Trees for Predicting Gold Nanorod Sizes from Spectra" J. Phys. Chem. C 2021, 125, 35, 19353–19361

Flatebo, C., Dutta, C., Ostovar, B., Link, S., Landes, C. F., "Heterogeneity and Hysteresis in the Polymer Collapse of Single Core–Shell Stimuli-Responsive Plasmonic Nanohybrids" J. Phys. Chem. C 2021, 125, 33, 18270–18278

Misiura, A., Shen, H., Tauzin, L., Dutta, C., Bishop, L. D. C., Carrejo, N. C., Zepeda O, J., Ramezani, S., Moringo, N. A., Marciel, A. B., Rossky, P. J., Landes, C. F., "Single-Molecule Dynamics Reflect IgG Conformational Changes Associated with Ion-Exchange Chromatography" Anal. Chem. 2021, 93, 32, 11200–11207

Al-Zubeidi, A., Stein, F., Flatebo, C., Rehbock, C., Hosseini Jebeli, S. A., Landes, C. F., Barcikowski, S., Link, S.,, "Single-Particle Hyperspectral Imaging Reveals Kinetics of Silver Ion Leaching from Alloy Nanoparticles" ACS Nano 2021, 15, 5, 8363–8375

Baiyasi, R., Goldwyn, H. J., McCarthy, L. A., West, C. A., Hosseini Jebeli, S. A., Masiello, D. J., Link, S., Landes, C. F., "Coupled-Dipole Modeling and Experimental Characterization of Geometry-Dependent Trochoidal Dichroism in Nanorod Trimers" ACS Photonics 2021, 8, 4, 1159–1168

Rice University
Chemistry Department
Smalley-Curl Institute
ECE Department