The Landes Research Group at Rice University

The Landes Research Group develops new spectroscopic tools to image chemical dynamics at interfaces at the limit of a single event. Using this super-resolved chemical knowledge, we create new models to understand and predict macroscale processes like protein separation and photocatalysis.


Ensemble vs. Single Molecule

A wide range of biological and materials processes rely on nanoscale interfacial dynamics. Single molecule methods allow us to identify the chemical complexity of these interactions by revealing the underlying populations that form the ensemble measurement. In doing so, we can identify and tune the rare chemical populations that play a crucial role in reactivity.

Towards Predictive Separations

The cost of bringing a new protein based therapeutic to market averages ~$2.6 billion dollars, of which 50% can be dedicated to isolating and purifying the active compound. A primary contributor to the cost is the empirical optimization of chromatographic separation. Our lab seeks to understand separations from the scale of individual analytes, with a goal to create a new predictive model of chromatography to eliminate the need for costly empirical methods.


Breaking the Abbe-Diffraction Limit

The Abbe diffraction limit sets a lower bound of a few hundred nanometers for the size of objects we can observe with traditional optical microscopy. This limit is defined by light’s wavelength. Our lab develops new mathematical methods to break the Abbe diffraction limit and achieve spatial resolutions of just a few nanometers and time resolutions faster than traditional cameras frame times.

Ph.D.   03/31/2021

Logan Bishop

Congratulations to Logan Bishop for successfully defending his Ph.D! Good luck at 3M!

Ph.D.   03/11/2021

Rashad Baiyasi

Congratulations to Rashad Baiyasi for passing his thesis defense. Good luck with the coming future!

Congratulations   08/10/2020

Anastasiia MisiuraLogan Bishop

Congratulations to Anastasiia Misiura and Logan Bishop for for winning Weiser Awards this year!

Promotion   04/27/2020

Jixin Chen

Congratulations to Landes Group Alum Prof. Jixin Chen for receiving tenure at Ohio University!

Predictive Separations

Predictive Separations



Protein Dynamics at Interfaces

Protein Dynamics at Interfaces

Imaging and Signal Processing

Imaging and Signal Processing

Single-Molecule Spectroscopy

Single-Molecule Spectroscopy

Baiyasi, R., Goldwyn, H. J., McCarthy, L. A., West, C. A., Hosseini Jebeli, S. A., Masiello, D. J., Link, S., Landes, C. F., "Coupled-Dipole Modeling and Experimental Characterization of Geometry-Dependent Trochoidal Dichroism in Nanorod Trimers" ACS Photonics 2021

Heiderscheit, T. S., Oikawa, S., Sanders, S., Minamimoto, H., Searles, E. K., Landes, C. F., Murakoshi, K., Manjavacas, A., Link, S., "Tuning Electrogenerated Chemiluminescence Intensity Enhancement Using Hexagonal Lattice Arrays of Gold Nanodisks" J. Phys. Chem. Lett. 2021, 2516-2522

Collins, S. S. E., Searles, E. K., Tauzin, L. J., Lou, M., Bursi, L., Liu, Y., Song, J., Flatebo, C., Baiyasi, R., Cai, Y. Y., Foerster, B., Lian, T., Nordlander, P., Link, S., Landes, C. F., "Plasmon Energy Transfer in Hybrid Nanoantennas" ACS Nano 2020

Calabrase, W., Bishop, L. D. C., Dutta, C., Misiura, A., Landes, C. F., Kisley, L., "Transforming Separation Science with Single-Molecule Methods" Anal. Chem. 2020, 92, 20, 13622-13629

Baiyasi, R., Gallagher, M.J., McCarthy, L.A., Searles, E.K., Zhaing, Q., Link, S., Landes, C.F., "Quantitative Analysis of Nanorod Aggregation and Morphology from Scanning Electron Micrographs Using SEMseg" J. Phys. Chem. A 2020, 124, 25, 5262–5270

Rice University
Chemistry Department
Smalley-Curl Institute
ECE Department